步文博：复旦大学，材料科学系/聚合物分子工程国家重点实验室，特聘教授（二级）、博士生导师，复旦大学交叉研究发展中心主任，首届上海市杰出人才（2023年）、国家杰出青年基金获得者（2017年）。2002年于南京工业大学获博士学位，同年进入中国科学院上海硅酸盐研究所工作，2005年晋升为副研究员，2008年破格晋升为研究员，2009年聘任为博士生导师，2011年起担任高性能陶瓷和超微结构国家重点实验室副主任；2016年3月，调入华东师范大学工作，曾担任上海市绿色化学与化工过程绿色化重点实验室常务副主任；2020年3月，作为特聘教授全职调入复旦大学材料科学系/聚合物分子工程国家重点实验室工作，现担任复旦大学交叉研究发展中心主任。
研究方向为材料生物学（招生专业：材料物理与化学）：1. 新型光电磁功能材料的合成方法学研究; 2. 稀土功能材料的光磁学、分子影像学与疾病（肿瘤）高效诊疗研究；3. 新型多功能材料用于脑科学研究（神经显像与神经调控）。
近年来，聚焦于材料生物学应用基础研究：发展了催化放疗增敏的新技术，引领并推动稀土上转换材料成为乏氧肿瘤诊疗研究的主流材料体系，获得上海市自然科学奖一等奖（2022年）；提出和引领化学动力学疗法成为一个全新的抗肿瘤新疗法，入选中科院与科睿唯安联合发布的《2021研究前沿》“重点热点前沿”；开拓了还原应激性损伤的肿瘤治疗新方向，入选 2022 Cell Press China Paper Award，并联合临床经动脉化疗栓塞术，推动还原损伤疗法向临床转化应用进程。研究成果在国际纳米医学领域产生了重要影响。
近年来，在国家自然科学基金委和上海市科委的资助下，作为项目负责人，先后主持承担了包括8项国家自然科学基金（杰青、重点、专项）在内的多项国家级科研项目。作为项目骨干，全程参与完成了包括973计划、863计划、国家自然基金重点项目等多项国家级科研项目。
近年来，作为通讯作者在“Nature Nanotechnology”（2篇）、“Chem”、“J. Am. Chem. Soc.”、“Angew. Chem. Int. Ed.”、“Adv. Mater.、“Sci. Adv.”、“Nature. Commun.”等国际核心SCI学术期刊上发表研究论文80余篇，受邀著名综述类学术期刊“Acc. Chem. Res.”、“Chem. Rev.”、“Chem. Soc. Rev.”等撰写6篇专题综述论文，论文SCI他引2.3万余次，连续五年入选Clarivate Analytics（科睿唯安）全球高被引科学家（2019-2023）；其中，1篇研究论文入选“中国百篇最具影响国际学术论文”，20余篇研究论文入选 ESI “Highly Cited Papers”，10余篇研究论文被 Nature/SciBX、Chemical& Engineering News、ChemistryViews、Asian Scientist、ChemistryWorld、Phys.org等国际著名专业新闻媒体作为研究亮点进行了专题报道和评述。获授权中国发明专利多项。
学术兼职：中国生物材料学会影像材料与技术分会候任主任委员、中国生物材料学会理事、中国生物医学工程学会生物材料分会委员、中国生物材料学会青年委员会委员、新型电子元器件基础材料及精细工艺国家重点实验室学委会委员、中国硅酸盐学会特种陶瓷分会理事、中国研究型医院学会消化内镜分子影像学专业委员会常务委员；国际学术期刊“BME Mat”副主编及The Innovation等多个国际学术期刊编委。
奖励及荣誉：首届上海市杰出人才（2023年），上海市自然科学奖一等奖（2022年，第一完成人），Clarivate Analytics（科睿唯安）全球高被引科学家（2019-2023年）， 国家杰出青年基金获得者（2017年入选，2022年结题评价为优秀A），科技部中青年科技创新领军人才（2017年），上海市优秀学术带头人计划（2016年），中国科学院优秀研究生指导教师奖（2016年）、上海市青年科技启明星跟踪计划（2012年），中国科学院上海分院第三届杰出青年科技创新人才提名奖（2012年），上海市长宁区第七轮专业技术拔尖人才奖（2010年）、第五届柳大纲优秀青年科技奖（2008年）、上海市青年科技启明星计划（2007年）、国防科学技术二等奖（2004年）等多项荣誉称号。
承担的科研项目（项目负责人）：
国家自然科学基金类（八项）：
1. 国家自然科学基金（重点），项目编号：22235004，期限：2023-2027，300万元（在研）
2. 国家自然科学基金（杰青），项目编号：51725202，期限：2018-2022，400万元（结题评价：A优秀）
3. 国家自然科学基金（面上），项目编号：51872094，期限：2019-2022， 60万元（结题）
4. 国家自然科学基金（面上），项目编号：51372260，期限：2014-2017， 80万元（结题）
5. 国家自然科学基金（专项），项目编号：50823007，期限：2009-2012，140万元（结题）
6. 国家自然科学基金（面上），项目编号：50972154，期限：2010-2012， 36万元（结题）
7. 国家自然科学基金（面上），项目编号：50672115，期限：2007-2009， 29万元（结题）
8. 国家自然科学基金（青年），项目编号：50502037，期限：2006-2006， 9万元（结题）
上海市基金类（四项）：
1.上海市基础重大研究计划（教委），项目编号：2023ZKZD01，期限：2023-2027，300万元（在研）
2.上海市基础重大研究计划（科委），项目编号：19JC1412000，期限：2019-2022，400万元（结题）
3. 纳米技术专项（重点），项目编号：11nm0505000，期限：2011-2014，50万元（结题）
4. 纳米技术专项（重点），项目编号：0852nm03900，期限：2008-2010，40万元（结题）
人才计划基金类（四项）：
1. 上海市优秀学术带头人计划，项目编号：16XD1404000，期限：2016-2019（结题）
2. 上海市人才发展资金资助计划，项目编号：2012035，期限：2012-2014（结题）
3. 上海市青年科技启明星计划（跟踪），项目编号：12QH1402500，期限：2012-2014（结题）
4. 上海市青年科技启明星计划（A类），项目编号：07QA14061，期限：2007-2009（结题）
项目合作与协作单位：
复旦大学附属中山医院
复旦大学附属华山医院
复旦大学附属华东医院
复旦大学附属肿瘤医院
同济大学附属第十人民医院
同济大学附属东方医院
海军军医大学附属长海医院
海军军医大学附属长征医院
National University of Singapore
The University of Queensland, Australia
University of Technology Sydney, Australia
Key Publications: （Update time: 2020-05-30）
Publication /Citation List:
https://so.cljtscd.com/citations?hl=zh-CN&user=7lOXzeoAAAAJ&view_op=list_works&sortby=pubdate
Selective Publications（Invited Review）：
1. Zhongmin Tang, Peiran Zhao, Han Wang, Yanyan Liu*, Wenbo Bu*.
Biomedicine meets Fenton chemistry.
Chemical Reviews, 2021, 121 (4), 1981-2019.
2. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia.
Chemical Reviews, 2017, 117(9): 6160-6224.
3. Dalong Ni, Wenbo Bu*, Weibo Cai, Jianlin Shi*.
Engineering of Inorganic Nanoparticles as Magnetic Resonance Imaging Contrast Agents.
Chemical Society Reviews,2017, 46, 7438–7468.
4. Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu*
Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment to Solid Tumors.
Accounts of Chemical Research, 2018, 51(10), 2502-2511.
5. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics.
Accounts of Chemical Research, 2015, 48 (7): 1797–1805..
6. Ya Wang, Huilin Zhang, Yanyan Liu, Muhsin H Younis, Weibo Cai, Wenbo Bu*
Catalytic radiosensitization: Insights from materials physicochemistry.
Materials Today, 2022, 57, 262-278.
7. Yanyan Liu, Xianfu Meng, Wenbo Bu*.
Upconversion-based Photodynamic Cancer Therapy.
Coordination Chemistry Reviews, 2019, 379, 82-98.
8. Peiran Zhao, Huiyan Li, Wenbo Bu*.
A Forward Vision for Chemodynamic Therapy: Issues and Opportunities
Angewandte Chemie International Edition, 2023, DOI: 10.1002/anie.202210415.
9. Zhongmin Tang, Yanyan Liu, Mingyuan He, Wenbo Bu*.
Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction.
Angewandte Chemie-International Edition, 2019, 58 (4), 946-956.
10. Wenpei Fan, Wenbo Bu*, Jianlin Shi
On The Latest Three-Stage Development of Nanomedicines Based on Upconversion Nanoparticles.
Advanced Materials, 2016, 28, 3987–4011.
11. Yanyan Liu, Meng Zhang, Wenbo Bu*
Bioactive nanomaterials for ion‐interference therapy.
View 2020, 1 (2), e33.
12. Functional CT Contrast Nanoagents for the Tumor Microenvironment
Xianfu Meng, Yelin Wu, Wenbo Bu*
Advanced Healthcare Materials, 2020, 2000912.
Selective Publications (Research Papers):
1. Yang Chen, Chaochao Wang, Yelin Wu, Ya Wang, Yun Meng, Fan Wu, Huilin Zhang, Yuen Yee Cheng, Xingwu Jiang, Jieyun Shi, Huiyan Li, Peiran Zhao, Jinfeng Wu*, Bin Zheng, Dayong Jin*, Wenbo Bu*
Nutrient-Delivery and Metabolism Reactivation Therapy for Melanoma.
Nature Nanotechnology, 2024, DOI: 10.1038/s41565-024-01690-6.
2. Chen Zhang, Dalong Ni, Yanyan Liu, Heliang Yao, Wenbo Bu*, Jianlin Shi*.
Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.
Nature Nanotechnology, 2017, 12 (4), 378-386.
3. Lijie Chen, Xingwu Jiang, Meng Lv, Xueli Wang, Peiran Zhao, Meng Zhang, Guanglei Lv, Jiyue Wu, Yanyan Liu, Yang Yang*, Jinquan Chen*, and Wenbo Bu*
Reductive damage induced intracellular maladaptation for cancer electronic interference therapy.
Chem. 2022, 8(3), 866-879.
4. Meng Zhang, Ruixue Song, Yanyan Liu, Zhigao Yi, Xianfu Meng, Jiawen Zhang, Zhongmin Tang, Zhenwei Yao, Yang Liu, Xiaogang Liu* and Wenbo Bu*
Calcium Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.
Chem, 2019, 5 (8): 2171-2182.
5. Yaqin Jiang, Pengfei Fu, Yanyan Liu*, Chaochao Wang, Peiran Zhao, Xu Chu, Xingwu Jiang, Wei Yang, Yelin Wu, Ya Wang, Guohua Xu*, Jin Hu, Wenbo Bu*
Near-infrared Light-Triggered NO Release for Spinal Cord Injury Repair.
Science Advances, 2020, 6 (39), eabc3513.
6. Jianan Liu, Limin Pan, Chunfeng Shang, Bin Lu, Rongjie Wu, Yun Feng, Weiyu Chen, Rongwei Zhang, Jiwen Bu, Zhiqi Xiong, Wenbo Bu*, Jiulin Du,* and Jianlin Shi*
A highly sensitive and selective nanosensor for near-infrared potassium imaging
Science Advances, 2020, 6 (16), eaax9757.
7. Jian Chen, Yanyan Liu, Feixiang Chen, Mengnan Guo, Jiajia Zhou, Pengfei Fu, Xin Zhang, Xueli Wang, He Wang, Wei Hua, Jinquan Chen, Jin Hu, Ying Mao*, Dayong Jin*, and Wenbo Bu*.
Non-Faradaic Optoelectrodes for Safe Electrical Neuromodulation
Nature Communications, 2024, 15, 405.
8. Yun Meng, Lijie Chen, Yang Chen, Jieyun Shi, Zheng Zhang, Yiwen Wang, Fan Wu, Xingwu Jiang, Wei Yang, Li Zhang, Chaochao Wang, Xianfu Meng, Yelin Wu*, Wenbo Bu*.
Reactive Metal Boride Nanoparticles Trap Lipopolysaccharide and Peptidoglycan for Bacteria-Infected Wound Healing.
Nature Communications, 2022, 13, 7353.
9. Zhigao Yi, Xujuan Qin, Li Zhang, Huan Chen, Tianlin Song, Zichao Luo, Tao Wang, Junwei Lau, Yelin Wu, Tan Boon Toh, Chun-Sing Lee*, Wenbo Bu*, Xiaogang Liu*.
Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish.
Journal of the American Chemical Society, 2024, 146, 9413-9421.
10. Jianan Liu, Rongwei Zhang, Chunfeng Shang, Yu Zhang, Yun Feng, Limin Pan, Bing Xu, Taeghwan Hyeon, Wenbo Bu*, Jianlin Shi* and Jiulin Du*
Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish.
Journal of the American Chemical Society, 2020, 142, 7858-7867.
11. Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Zhao Li, Ying Kong, Yuanhua Sang, Hong Liu*, Wenbo Bu*, and Linlin Li*
Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Triggered Chemodynamic Therapy.
Journal of the American Chemical Society, 2019, 141 (2), 849-857.
12. Chen Zhang, Wenbo Bu*, Dalong Ni, Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin Shi*.
A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.
Journal of the American Chemical Society, 2016, 138 (26), 8156–8164.
13. Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, Jianlin Shi*.
Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.
Journal of the American Chemical Society, 2014, 136 (27), 9701–9709.
14. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy.
Journal of the American Chemical Society, 2013, 135 (35), 13041-13048.
15. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.
Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging.
Journal of the American Chemical Society, 2013, 135 (17), 6494-6503.
16. Peiran Zhao, Huiyan Li, Bingxia Sun, Chaochao Wang, Guanglei Lv, Chao Chen, Leilei Ying, Xinhong He*, Dayong Jin*, and Wenbo Bu*.
Carbon Free Radical (R∙) Inactivates NF‐κB for Radical Capping Therapy.
Angewandte Chemie-International Edition, 2024, DOI: 10.1002/anie.202405913.
17. Huilin Zhang, Yang Chen, Wei Hua, Wenjun Gu, Hongjun Zhuang, Huiyan Li, Xingwu Jiang, Ying Mao,* Yanyan Liu,* Dayong Jin and Wenbo Bu*.
Heterostructures with Built-in Electric Fields for Long-lasting Chemodynamic Therapy.
Angewandte Chemie-International Edition, 2023, DOI: 10.1002/anie. 202300356.
18. Fan Wu, Yanli Li, Yun Meng, Xuechao Cai, Jieyun Shi, Jinjin Li, Yang Chen, Li Zhang, Xianfu Meng, Huiyan Li, Xingwu Jiang, Zhenxiao Fu, Yelin Wu,* and Wenbo Bu*.
An Ion-Enhanced Oncolytic Virus-Like Nanoparticle for Tumor Immunotherapy.
Angewandte Chemie International Edition, 2022, 134 (45), e202210487.
19. Xiaoyan Chen, Yang Chen, Chaochao Wang, Yaqin Jiang, Xu Chu, Fan Wu, Yelin Wu, Xuechao Cai, Yi Cao,* Yanyan Liu,* and Wenbo Bu*.
NIR-triggered intracellular H+ transients for lamellipodia-collapsed antimetastasis and enhanced chemodynamic therapy.
Angewandte Chemie-International Edition, 2021, 60, 21905-21910.
20. Yanli Li, Teng Gong,* Hongbao Gao, Yang Chen, Huiyan Li, Peiran Zhao, Yaqin Jiang, Kun Wang, Yelin Wu, Xiangpeng Zheng,* and Wenbo Bu*
ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy.
Angewandte Chemie-International Edition, 2021, 60, 15472–1548.
21. Peiran Zhao, Yaqin Jiang, Zhongmin Tang, Yanli Li, Bingxia Sun, Yelin Wu, Jiyue Wu,Yanyan Liu,* Wenbo Bu*
Constructing Electron lever in Perovskite Nanocrystal to Regulate Local Electron Density for Intensive Chemodynamic Therapy.
Angewandte Chemie-International Edition, 2021, 60, 8905–8912.
22. Ruixue Song, Han Wang, Meng Zhang, Yanyan Liu, Xianfu Meng, Shaojie Zhai, Chaochao Wang, Teng Gong, Yelin Wu, Xingwu Jiang, Mingyuan He, Wenbo Bu*
Near-infrared Light-triggered Chlorine Radicals (•Cl) Stress for Cancer Therapy.
Angewandte Chemie-International Edition, 2020, 59, 21032–21040.
23. Yanli Li, Peiran Zhao, Teng Gong*, Meng Zhang, Hui Cheng, Yanyan Liu, Yelin Wu*, Wenbo Bu*.
Redox Dyshomeostasis Strategy for Hypoxia Tumor Therapy.
Angewandte Chemie-International Edition, 2020, 59, 22537–22543.
24. Chen Zhang, Wenbo Bu*, Dalong Ni, Shenjian Zhang, Qing Li, Zhenwei Yao, Jiawen Zhang, Heliang Yao, Zheng Wang, Jianlin Shi*
Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.
Angewandte Chemie-International Edition, 2016, 55, 2101-2106.
25. Wenpei Fan, Wenbo Bu*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi*.
X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.
Angewandte Chemie-International Edition, 2015, 54, 14026–14030.
26. Yanyan Liu, Yong Liu, Wenbo Bu*, Chao Cheng, Changjing Zuo, Qingfeng Xiao, Yong Sun, Dalong Ni, Chen Zhang, Jianan Liu, Jianlin Shi*.
Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.
Angewandte Chemie-International Edition, 2015, 54, 8105–8109.
27. Chen Zhang, Kuaile Zhao, Wenbo Bu*, Dalong Ni, Yanyan Liu, Jingwei Feng, Jianlin Shi*.
Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence.
Angewandte Chemie-International Edition, 2015, 54: 1770–1774.
28. Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangpin Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, Jianlin Shi*.
Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging．
Angewandte Chemie-International Edition, 2014, 53, 4551-4555.
29. Jianan Liu, Wenbo Bu*, Limin Pan, Jianlin Shi*.
NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica.
Angewandte Chemie-International Edition, 2013, 52, 4375-4379.
30. Jiyue Wu, Yun Meng, Fan Wu, Jieyun Shi, Qingwen Sun, Xingwu Jiang, Yanyan Liu, Peiran Zhao, Qiao Wang, Lehang Guo, Yelin Wu*, Xiangpeng Zheng*, Wenbo Bu*.
Ultrasound-driven Non-metallic Fenton-active Center Construction for Extensive Chemodynamic Therapy.
Advanced Materials, 2024, 36(2), 2307980.
31. Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao*, Jian Wu*, Wenbo Bu*.
Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepter.
Advanced Materials, 2023, DOI:10.1002/adma. 202211597.
32. Xu Chu, Hongjun Zhuang, Yanyan Liu*, Jinjin Li, Ya Wang, Yaqin Jiang, Huilin Zhang, Peiran Zhao, Yang Chen, Xingwu Jiang, Yelin Wu, Wenbo Bu*.
Blocking Cancer‐Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain
Advanced Materials, 2022, DOI:10.1002/adma.202108653.
33. Huilin Zhang, Jinjin Li, Yang Chen, Jiyue Wu, Kun Wang, Lije Chen, Ya Wang, Xingwu Jiang, Yanyan Liu, Yelin Wu, Dayong Jin, Wenbo Bu*
Magneto-electrically enhanced intracellular catalysis of FePt-FeC heterostructures for cancer chemodynamic therapy.
Advanced Materials, 2021, 33 (17), 2100472.
34. Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin Lv, Han Wang, Dayong Jin, Wenbo Bu*
Biodegradable Nanoprodrugs: Delivering ROS To Cancer Cells For Molecular Dynamics Therapy.
Advanced Materials, 2020, 32 (4), 1904011.
35. Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu*.
Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy.
Advanced Materials, 2017, 29, 1701683.
36. Wenpei Fan, Wenbo Bu*, Bo Shen, Qianjun He, Zhaowen Cui, Yanyan Liu, Xiangpeng Zheng, Kuaile Zhao, Jianlin Shi*.
Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy.
Advanced Materials, 2015, 27, 4155–4161.
37. Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
Ultrasmall NaGdF4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging．
Advanced Materials, 2014, 26, 3867–3872.
☆ 年度论文列表：
2024年
1. Yang Chen, Chaochao Wang, Yelin Wu, Ya Wang, Yun Meng, Fan Wu, Huilin Zhang, Yuen Yee Cheng, Xingwu Jiang, Jieyun Shi, Huiyan Li, Peiran Zhao, Jinfeng Wu*, Bin Zheng, Dayong Jin*, Wenbo Bu*
Nutrient-Delivery and Metabolism Reactivation Therapy for Melanoma
Nature Nanotechnology, 2024, DOI: 10.1038/s41565-024-01690-6.
2. Jian Chen, Yanyan Liu, Feixiang Chen, Mengnan Guo, Jiajia Zhou, Pengfei Fu, Xin Zhang, Xueli Wang, He Wang, Wei Hua, Jinquan Chen, Jin Hu, Ying Mao*, Dayong Jin*, and Wenbo Bu*.
Non-Faradaic Optoelectrodes for Safe Electrical Neuromodulation
Nature Communications, 2024, 15, 405.
3. Zhigao Yi, Xujuan Qin, Li Zhang, Huan Chen, Tianlin Song, Zichao Luo, Tao Wang, Junwei Lau, Yelin Wu, Tan Boon Toh, Chun-Sing Lee*, Wenbo Bu*, Xiaogang Liu*.
Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish.
Journal of the American Chemical Society, 2024, 146, 9413-9421.
4. Peiran Zhao, Huiyan Li, Bingxia Sun, Chaochao Wang, Guanglei Lv, Chao Chen, Leilei Ying, Xinhong He*, Dayong Jin*, and Wenbo Bu*.
Carbon Free Radical (R∙) Inactivates NF‐κB for Radical Capping Therapy.
Angewandte Chemie-International Edition, 2024, DOI: 10.1002/anie.202405913.
5. Jiyue Wu, Yun Meng, Fan Wu, Jieyun Shi, Qingwen Sun, Xingwu Jiang, Yanyan Liu, Peiran Zhao, Qiao Wang, Lehang Guo, Yelin Wu*, Xiangpeng Zheng*, Wenbo Bu*.
Ultrasound-driven Non-metallic Fenton-active Center Construction for Extensive Chemodynamic Therapy.
Advanced Materials, 2024, 36(2), 2307980.
6. Tao Wang, Chaochao Wang, Ya Wang, Xuelian Zhang, Xuechao Cai, Zhongqiu Guo, Xianfu Meng, Xingwu Jiang, Yelin Wu, Yi Cao*, Changjing Zuo*, Wenbo Bu*.
Radioiodine‐Mediated Transition Metal Valence Conversion for Enhanced Chemodynamic Therapy.
Advanced Functional Materials 2024, DOI: 10.1002/adfm.2024007911.
2023年
1. Peiran Zhao, Huiyan Li*, Wenbo Bu*.
A Forward Vision for Chemodynamic Therapy: Issues and Opportunities.
Angewandte Chemie-International Edition, 2023, 62, e202210415.
2. Huilin Zhang, Yang Chen, Wei Hua, Wenjun Gu, Hongjun Zhuang, Huiyan Li, Xingwu Jiang, Ying Mao,* Yanyan Liu,* Dayong Jin and Wenbo Bu*.
Heterostructures with Built-in Electric Fields for Long-lasting Chemodynamic Therapy.
Angewandte Chemie-International Edition, 2023, DOI: 10.1002/anie. 202300356.
3. Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao*, Jian Wu*, Wenbo Bu*.
Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepter
Advanced Materials, 2023, DOI:10.1002/adma.202108653.
4. Hongjun Zhuang, Xiaofang He, Huiyan Li, Yang Chen, Tong Wu, Xingwu Jiang, Huilin Zhang, Peiran Zhao, Ya Wang, Jian Chen, Jian Zhang, Yanyan Liu*, Wenbo Bu*.
MnS Nanocapsule Mediates Mitochondrial Membrane Permeability Transition for Tumor Ion-Interference Therapy.
ACS Nano, 2023, 17(14), 13872-13884.
5. Xianfu Meng, Jiahao Gao, Yanhong Sun, Fei Duan, Bixue Chen, Guanglei Lv, Huiyan Li, Xingwu Jiang, Yelin Wu, Jiawen Zhang, Xiangming Fang*, Zhenwei Yao, Changjing Zuo*, Wenbo Bu*
Fusing Positive and Negative CT Contrast Nanoagent for the Sensitive Detection of Hepatoma.
Advanced Science, 2023, 10(34), 2304668.
2022年
1. Lijie Chen, Xingwu Jiang, Meng Lv, Xueli Wang, Peiran Zhao, Meng Zhang, Guanglei Lv, Jiyue Wu, Yanyan Liu, Yang Yang*, Jinquan Chen*, and Wenbo Bu*.
Reductive-damage-induced intracellular maladaptation for cancer electronic interference therapy.
Chem, 2022, 8, 866-879.
2. Yun Meng, Lijie Chen, Yang Chen, Jieyun Shi, Zheng Zhang, Yiwen Wang, Fan Wu, Xingwu Jiang, Wei Yang, Li Zhang, Chaochao Wang, Xianfu Meng, YelinWu*, Wenbo Bu*.
Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for
bacteria-infected wound healing.
Nature communications, 2022, 13, 7353.
4. Fan Wu, Yanli Li, Yun Meng, Xuechao Cai, Jieyun Shi, Jinjin Li, Yang Chen, Li Zhang, Xianfu Meng, Huiyan Li, Xingwu Jiang, Zhenxiao Fu, Yelin Wu*, Wenbo Bu*.
An Ion-Enhanced Oncolytic Virus-Like Nanoparticle for Tumor Immunotherapy.
Angewandte Chemie-International Edition, 2022, 61, e202210487.
3. Xu Chu, Hongjun Zhuang, Yanyan Liu*, Jinjin Li, Ya Wang, Yaqin Jiang, Huilin Zhang, Peiran Zhao, Yang Chen, Xingwu Jiang, Yelin Wu, Wenbo Bu*.
Blocking Cancer–Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain.
Advanced Materials, 2022, 34, 2108653.
5. Ya Wang, Huilin Zhang, Yanyan Liu, Muhsin H. Younis, Weibo Cai*, Wenbo Bu*.
Catalytic radiosensitization: Insights from materials physicochemistry.
Materials Today, 2022, 57, 262-278. (Invited Review)
6. Kun Wang, Jinjin Lia, Yan Yi, Bin Lv, Yelin Wu*, Chaochao Wang, Huiyan Li, Yanli Li, Yang Liu, Xuechao Cai, Xianfu Meng, Xingwu Jiang, Xiangpeng Zheng*, Zhaocai Zhou, Wenbo Bu*.
Polyamine-activated carbonyl stress strategy for oxidative damage therapy.
Nano Today, 2022, 42, 101355.
7. Xianfu Meng, Yan Yi, Yun Meng, Guanglei Lv, Xingwu Jiang, Yelin Wu, Wei Yang, Yefeng Yao, Huixiong Xu*, Wenbo Bu*.
Self-Enhanced Acoustic Impedance Difference Strategy for Detecting the Acidic Tumor Microenvironment.
ACS Nano, 2022, 16, 4217−4227.
8. Zhongmin Tang, Shiman Wu, Peiran Zhao, Han Wang, Dalong Ni, Huiyan Li, Xingwu Jiang, Yelin Wu*, Yun Meng, Zhenwei Yao*, Weibo Cai, and Wenbo Bu*.
Chemical Factory-Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer.
Advanced Science, 2022, 9, 2201232.
9. Yelin Wu, Yanli Li, Guanglei Lv, Wenbo Bu*.
Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry.
Chemical Science, 2022, 13, 2202-2217. (Invited Review)
2021年
1. Zhongmin Tang, Peiran Zhao, Han Wang, Yanyan Liu*, Wenbo Bu*.
Biomedicine meets Fenton chemistry.
Chemical Reviews, 2021, 121 (4), 1981-2019. (Invited Review)
2. Xiaoyan Chen, Yang Chen, Chaochao Wang, Yaqin Jiang, Xu Chu, Fan Wu, Yelin Wu, Xuechao Cai, Yi Cao,* Yanyan Liu,* and Wenbo Bu*.
NIR-triggered intracellular H+ transients for lamellipodia-collapsed antimetastasis and enhanced chemodynamic therapy.
Angewandte Chemie-International Edition, 2021,60, 21905-21910.
3. Yanli Li, Teng Gong,* Hongbao Gao, Yang Chen, Huiyan Li, Peiran Zhao, Yaqin Jiang, Kun Wang, Yelin Wu, Xiangpeng Zheng,* and Wenbo Bu*
ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy.
Angewandte Chemie-International Edition, 2021, 60, 15472-15481.
4. Peiran Zhao, Yaqin Jiang, Zhongmin Tang, Yanli Li, Bingxia Sun, Yelin Wu, Jiyue Wu, Yanyan Liu,* Wenbo Bu*
Constructing Electron lever in Perovskite Nanocrystal to Regulate Local Electron Density for Intensive Chemodynamic Therapy.
Angewandte Chemie-International Edition, 2021, 60, 8905–8912.
5. Huilin Zhang, Jinjin Li, Yang Chen, Jiyue Wu, Kun Wang, Lije Chen, Ya Wang, Xingwu Jiang, Yanyan Liu, Yelin Wu, Dayong Jin, Wenbo Bu*
Magneto-electrically enhanced intracellular catalysis of FePt-FeC heterostructures for cancer chemodynamic therapy.
Advanced Materials, 2021, 33 (17), 2100472.
6. Han Wang, Hongbo Gao, Xingwu Jiang, Peiran Zhao, Dalong Ni, Zhongmin Tang, Yanyan Liu,* Xiangpeng Zheng,b,* Wenbo Bu*.
Regulating Water States by Vacancies for Cancer Therapy
Nano Today, 2021, 37, 101099.
7. Geyong Guo, Teng Gong, Hao Shen, Qiaojie Wang, Feng Jiang, Jin Tang, Xingwu Jiang, Jiaxing Wang,* Xianlong Zhang,* and Wenbo Bu*
Self-Amplification Immunomodulatory Strategy for Tissue Regeneration in Diabetes Based on Cytokine-ZIFs System.
Advanced Functional Materials 2021, 31, 2100795.
8. Xu Chu, Xingwu Jiang, Yanyan Liu*, Shaojie Zhai, Yaqin Jiang, Yang Chen, Jun Wu, Ya Wang, Yelin Wu, Xiaofeng Tao, Xinhong He*, and Wenbo Bu*
Nitric Oxide Modulating Calcium Store for Ca2+-initiated Cancer Therapy.
Advanced Functional Materials 2021, 31, 2008507.
9. Yang Liu, Shaojie Zhai, Xingwu Jiang*, Yanyan Liu, Kun Wang, Chaochao Wang, Meng Zhang, Xuanyong Liu*, and Wenbo Bu*
Intracellularmutual promotion of redox homeostasis regulation and iron metabolism disruption for enduring chemodynamic therapy.
Advanced Functional Materials, 2021, 31, 2010390.
10. Shiman Wu, Xianfu Meng, Xingwu Jiang, Yelin Wu, Shaojie Zhai, Xiaoshuang Wang, Yanyan Liu, Jiawen Zhang, Xinxin Zhao, Yan Zhou*, Wenbo Bu*, Zhenwei Yao*.
Harnessing X-ray Energy Dependent Attenuation of Bismuth-Based Nanoprobes for Accurate Diagnosis of Liver Fibrosis.
Advanced Science, 2021, 8, 2002548.
11. Xianfu Meng, Yelin Wu*, Wenbo Bu*
Functional CT Contrast Nanoagents for the Tumor Microenvironment
Advanced Healthcare Materials, 2021, 10 (5), 2000912.
2020年
1. Yaqin Jiang, Pengfei Fu, Yanyan Liu*, Chaochao Wang, Peiran Zhao, Xu Chu, Xingwu Jiang, Wei Yang, Yelin Wu, Ya Wang, Guohua Xu*, Jin Hu, Wenbo Bu*
Near-infrared Light-Triggered NO Release for Spinal Cord Injury Repair.
Science Advances, 2020, 6 (39), eabc3513.
2. Jianan Liu, Limin Pan, Chunfeng Shang, Bin Lu, Rongjie Wu, Yun Feng, Weiyu Chen, Rongwei Zhang, Jiwen Bu, Zhiqi Xiong, Wenbo Bu*, Jiulin Du,* and Jianlin Shi*
A highly sensitive and selective nanosensor for near-infrared potassium imaging
Science Advances, 2020, 6 (16), eaax9757.
3. Jianan Liu, Rongwei Zhang, Chunfeng Shang, Yu Zhang, Yun Feng, Limin Pan, Bing Xu, Taeghwan Hyeon, Wenbo Bu*, Jianlin Shi* and Jiulin Du*
Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish.
Journal of the American Chemical Society, 2020, 142, 7858-7867.
4. Ruixue Song, Han Wang, Meng Zhang, Yanyan Liu, Xianfu Meng, Shaojie Zhai, Chaochao Wang, Teng Gong, Yelin Wu, Xingwu Jiang, Mingyuan He, Wenbo Bu*
Near-infrared Light-triggered Chlorine Radicals (•Cl) Stress for Cancer Therapy
Angewandte Chemie-International Edition, 2020, 59, 21032–21040.
5. Yanli Li, Peiran Zhao, Teng Gong*, Meng Zhang, Hui Cheng, Yanyan Liu, Yelin Wu*, Wenbo Bu*.
Redox Dyshomeostasis Strategy for Hypoxia Tumor Therapy.
Angewandte Chemie-International Edition, 2020, 59, 22537–22543.
6. Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin Lv, Han Wang, Dayong Jin, Wenbo Bu*
Biodegradable Nanoprodrugs: Delivering ROS To Cancer Cells For Molecular Dynamics Therapy.
Advanced Materials, 2020, 32, 1904011.
7. Xiaoyan Chen, Huilin Zhang, Meng Zhang, Peiran Zhao, Ruixue Song, Teng Gong, Yanyan Liu*, Xinhong He*, Kuaile Zhao, and Wenbo Bu*
Amorphous Fe–based Nanoagents for Self–enhanced Chemodynamic Therapy by Re-establishing Tumor Acidosis.
Advanced Functional Materials 2020, 30 (6), 1908365.
8. Bin Lv, Huilin Zhang, Xiangpeng Zheng,* Han Wang, Weiqiang Ge,Yanping Ren, Zi Tan, Meng Zhang, Zhongmin Tang, Yanyan Liu, Libo Zhang, Yelin Wu, Xingwu Jiang, Wenbo Bu*.
Structure-oriented catalytic radiosensitization for cancer radiotherapy.
Nano Today, 2020, 35, 100988.
9. Weiwei Su, Han Wang, Tao Wang, Xiao Li, Zhongmin Tang, Shuai Zhao, Meng Zhang, Danni Li, Xingwu Jiang, Teng Gong, Wei Yang, Changjing, Zuo*, Yelin Wu*, Wenbo Bu*.
Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy.
Advanced Science, 2020, 7 (10), 1903585.
10. Teng Gong, Yanli Li, Bin Lv, Han Wang, Yanyan Liu*, Yelin Wu, Xingwu Jiang, Hongbo Gao, Xiangpeng Zheng*, Wenbo Bu*.
Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks.
ACS Nano, 2020, 14(3), 3032-3040.
11. Geyong Guo, Huilin Zhang, Hao Shen, Chongzun Zhu, Renke He, Jin Tang, Ya Wang, Xingwu Jiang, Jiaxing Wang,* Wenbo Bu*, Xianlong Zhang*.
Space-Selective Chemodynamic Therapy of CuFe5O8 Nanocubes for Implant-Related Infections.
ACS Nano, 2020, 14 (10), 13391-13405.
12. Chaochao Wang, Peiran Zhao, Guoliang Yang, Xiaoyan Chen, Yaqin Jiang, Meng Zhang, Xingwu Jiang, Yelin Wu, Yanyan Liu, Weian Zhang,* Wenbo Bu*.
Reconstructing the Intracellular pH Microenvironment for Enhancing Photodynamic Therapy.
Materials Horizons, 2020, 7, 1180-1185.
13. Weiwei Su, Chen Chen, Tao Wang, Xiao Li, Yanyan Liu, Han Wang, Danni Li, Shuai Zhao, Changjing Zuo,* Gaofeng Sun,* Wenbo Bu*.
Radionuclide Labeled Gold Nanoparticles for Nuclei-Targeting Internal Radio-Immunity Therapy.
Materials Horizons, 2020, 7, 1115 - 1125.
14. Xianfu Meng, Boyu Zhang, Yan Yi, Hui Cheng, Baoming Wang, Yanyan Liu, Teng Gong, Wei Yang, Yefeng Yao, He Wang*, and Wenbo Bu*.
Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT.
Nano Letters. 2020, 20 (4), 2522-2529.
15. Yang Liu, Shiman Wu, Yanyan Liu*, Hua Zhang, Meng Zhang, Zhongmin Tang, Yan Wang, Teng Gong, Zhenwei Yao, Xiangming Fang*, Wenbo Bu*.
Cathodic Protected Mn2+ by NaxWO3 Nanorods for Stable Magnetic Resonance Imaging-Guided Tumor Photothermal Therapy.
Biomaterials, 2020, 234, 119762.
16. Kun Wang, Huilin Zhang, Aijun Shen, Peiran Zhao, Xianfu Meng, Xiaoyan Chen, Yang Liu, Yanyan Liu, Teng Gong, Wanlu Wu, Xiangming Fang*, Peijun Wang, Wenbo Bu*
Magnetic Resonance Energy Transfer for in vivo Glutathione Susceptibility Weighted Imaging.
Biomaterials, 2020, 232, 119703.
17. Chaolin Song, Xianfu Meng, Yanyan Liu*, Aijun Sheng, Chulun Shao, Kun Wang, Hui Cheng, Xiangming Fang*, Peijun Wang, Wenbo Bu*
Susceptibility-weighted Imaging for Metabolic Pathway Mapping of Low-dosage Nanoparticles in Organisms.
Biomaterials, 2020, 230, 119631.
18. Xuan Mei, Tingting Hu, Hui Wang, Ruizheng Liang*, Wenbo Bu*, Min Wei*
Biomaterials, 2020, 258, 120257.
19. Yanyan Liu, Meng Zhang, Wenbo Bu*
Bioactive nanomaterials for ion‐interference therapy.
View 2020, 1 (2), e33. (Invited Review)
20. Chaochao Wang, Peiran Zhao, Dawei Jiang, Guoliang Yang, Yudong Xue, Zhongmin Tang, Meng Zhang, Han Wang, Xingwu Jiang, Yelin Wu, Yanyan Liu, Weian Zhang,* Wenbo Bu*
In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor
ACS Applied Materials & Interfaces 2020, 12 (5), 5624-5632
21. Chemodynamic therapy: integration of Fenton chemistry and biomedicine
Xiaoyan Chen, Yanyan Liu, Wenbo Bu*
Scientia Sinica Chimica 2020, 50 (2), 159-172.
2019年
1. Yanyan Liu, Xianfu Meng, Wenbo Bu*.
Upconversion-based Photodynamic Cancer Therapy.
Coordination Chemistry Reviews, 2019, 379, 82-98. (Invited Review)
2. Meng Zhang, Ruixue Song, Yanyan Liu, Zhigao Yi, Xianfu Meng, Jiawen Zhang, Zhongmin Tang, Zhenwei Yao, Yang Liu, Xiaogang Liu* and Wenbo Bu*
Calcium Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.
Chem, 2019, 5 (8): 2171-2182.
3. Baojin Ma, Shu Wang, Feng Liu, Shan Zhang, Jiazhi Duan, Zhao Li, Ying Kong, Yuanhua Sang, Hong Liu*, Wenbo Bu*, and Linlin Li*
Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Triggered Chemodynamic Therapy.
Journal of the American Chemical Society, 2019, 141 (2), 849-857.
4. Zhongmin Tang, Yanyan Liu, Mingyuan He, Wenbo Bu*.
Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reaction.
Angewandte Chemie-International Edition, 2019, 58 (4), 946-956.
5. Xiaoyan Chen, Huilin Zhang, Meng Zhang, Peiran Zhao, Ruixue Song, Teng Gong, Yanyan Liu*, Xinhong He*, Kuaile Zhao, and Wenbo Bu*
Amorphous Fe–based Nanoagents for Self–enhanced Chemodynamic Therapy by Re-establishing Tumor Acidosis.
Advanced Functional Materials, 2019, 30, 1908365.
6. Aijun Shen, Xianfu Meng, Xiaolong Gao, Xiaowen Xu, Chulun Shao, Zhongmin Tang, Yanyan Liu, Wenbo Bu*, and Peijun Wang*
Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under 3.0T Magnetic Field.
Advanced Functional Materials, 2019, 29, 1803832.
7. Xianfu Meng, Hua Zhang, Meng Zhang, Baoming Wang, Yanyan Liu, Yan Wang, Xiangming Fang*, Jiawen Zhang, Zhenwei Yao*, Wenbo Bu*
Negative CT contrast agents for the diagnosis of malignant osteosarcoma.
Advanced Science, 2019, 6, 1901214.
8. Meng Zhang, Bo Shen, Ruixue Song, Han Wang, Bin Lv, Xianfu Meng, Yang Liu, Yanyan Liu, Xiangpeng Zheng, Weiwei Su, Changjing Zuo*, and Wenbo Bu*.
Radiation-Assisted Metal Ion Interference Tumor Therapy by Barium Peroxide-Based nanoparticles.
Materials Horizons, 2019, 6, 1034 -1040.
9. Peiran Zhao, Zhongmin Tang, Xiaoyan Chen, Ziyu He, Xinhong He, Meng Zhang, Yanyan Liu, Dongdong Ren,* Kuaile Zhao and Wenbo Bu*.
Ferrous-Cysteine-Phosphotungstate Nanoagent with Neutral pH Fenton Reaction Activity for Enhanced Cancer Chemodynamic Therapy
Materials Horizons, 2019, 6, 369-374.
10. Chen Chen, Weiwei Su, Yanyan Liu, Jiawen Zhang, Changjing Zuo*, Zhenwei Yao, Wenbo Bu*.
Artificial Anaerobic Cell Dormancy for Tumor Gaseous Microenvironment Regulation Therapy.
Biomaterials, 2019, 200, 48-55.
2018年
1. Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu*
Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment to Solid Tumors.
Accounts of Chemical Research, 2018, 51(10), 2502-2511. (Invited Review)
2. Yingying Jin, Dalong Ni, Lu Gao, Xianfu Meng, Yi Lv, Fang Han, Hua Zhang, Yanyan Liu, Zhenwei Yao, Xiaoyuan Feng, Wenbo Bu,* Jiawen Zhang*.
Harness the Power of Upconversion Nanoparticles for Spectral Computed Tomography Diagnosis of Osteosarcoma.
Advanced Functional Materials, 2018, 28, 1802656.
3. Chulun Shao, Aijun Shen, Meng Zhang, Xianfu Meng, Chaolin Song, Xiaolong Gao, Yanyan Liu, Peijun Wang*, Wenbo Bu*.
Oxygen Vacancies-Enhanced CeO2: Gd Nanoparticles for Sensing Tumor Vascular Microenvironment by MRI.
ACS Nano, 2018, 12 (12), 12629–12637.
4. Zhongmin Tang, Peiran Zhao, Dalong Ni, Yanyan Liu, Meng Zhang, Han Wang, Hua Zhang, Hongbo Gao, Zhenwei Yao, Wenbo Bu*.
Pyroelectric nanoplatform for NIR-ΙΙ triggered photothermal therapy with simultaneous pyroelectric dynamic therapy.
Materials Horizons, 2018, 5, 946 – 952.
5. Han Wang, Bin Lv, Zhongmin Tang, Meng Zhang, Weiqiang Ge, Yanyan Liu, Xinhong He, Kuaile Zhao, Xiangpeng Zheng, Mingyuan He, and Wenbo Bu*.
Scintillator-based Nanohybirds with Sacrificial Electron Prodrug for Enhanced X-ray-induced Photodynamic Therapy.
Nano Letters. 2018, 18(9): 5768-5774.
6. Hua Zhang, Yue Wu, Jing Wang, Zhongmin Tang, Yan Ren, Dalong Ni, Hongbo Gao, Ruixue Song, Teng Jin, Qiao Li, Wenbo Bu*, Zhenwei Yao*.
In vivo MR Imaging of Glioma Recruitment of Adoptive T Cells Labeled with NaGdF4-TAT Nanoprobes.
Small, 2018, 14, 1702951.
7. Ruixue Song, Meng Zhang, Yanyan Liu, Zhaowen Cui, Hua Zhang, Zhongmin Tang, Xiaoyan Chen, Haihong Wu*, Zhenwei Yao*, Mingyuan He, Wenbo Bu*.
A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor.
Biomaterials, 2018, 175, 123-133.
8. Meng Zhang, Zhaowen Cui, Ruixue Song, Bin Lv, Zhongmin Tang, Xianfu Meng, Xiaoyan Chen, Xiangpeng Zheng, Jiawen Zhang, Zhenwei Yao, Wenbo Bu*
SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy.
Biomaterials, 2018, 155, 135-144.
2017年
1. Chen Zhang, Dalong Ni, Yanyan Liu, Heliang Yao, Wenbo Bu*, Jianlin Shi*.
Magnesium silicide nanoparticles as a deoxygenation agent for cancer starvation therapy.
Nature Nanotechnology, 2017, 12 (4), 378-386.
2. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia.
Chemical Reviews, 2017, 117(9): 6160-6224. (Invited Review)
3. Dalong Ni, Wenbo Bu*, Weibo Cai, Jianlin Shi*.
Engineering of Inorganic Nanoparticles as Magnetic Resonance Imaging Contrast Agents.
Chemical Society Reviews,2017, 46, 7438–7468. (Invited Review)
4. Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu*.
Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy.
Advanced Materials, 2017, 29, 1701683.
5. Dalong Ni, Jiawen Zhang, Jing Wang, Ping Hu, Yingying Jin, Zhongmin Tang, Zhenwei Yao, Wenbo Bu*, Jianlin Shi*.
Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd3+-Doped Contrast Agent.
ACS Nano, 2017, 11 (4), 4256–4264.
6. Han Qiao, Zhaowen Cui, Shengbing Yang, Dingkun Ji, Yugang Wang, Ying Yang, Xiuguo Han, Qiming Fan, An Qin, Tingyu Wang, Xiao-Peng He, Wenbo Bu*, Tingting Tang*.
Targeting Osteocyte to Attenuate Early Breast Cancer Bone Metastasis by Theranostic Upconversion-Nanoparticles with Responsive Plumbagin Release.
ACS Nano, 2017, 11 (7), 7259–7273.
7. Ping Hu, Tong Wu, Wenpei Fan, Lei Chen, Yanyan Liu, Dalong Ni, Wenbo Bu*, Jianlin Shi*.
Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy.
Biomaterials, 2017, 141, 86-95.
2016年
1. Chen Zhang, Wenbo Bu*, Dalong Ni, Changjing Zuo, Chao Cheng, Qing Li, Linlin Zhang, Zheng Wang, Jianlin Shi*.
A Polyoxometalate Cluster Paradigm with Self-Adaptive Electronic Structure for Acidity/Reducibility-Specific Photothermal Conversion.
Journal of the American Chemical Society, 2016, 138 (26), 8156–8164.
2. Chen Zhang, Wenbo Bu*, Dalong Ni, Shenjian Zhang, Qing Li, Zhenwei Yao, Jiawen Zhang, Heliang Yao, Zheng Wang, Jianlin Shi*
Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction.
Angewandte Chemie-International Edition, 2016, 55, 2101-2106.
3. Wenpei Fan, Wenbo Bu*, Jianlin Shi
On The Latest Three-Stage Development of Nanomedicines based on Upconversion Nanoparticles.
Advanced Materials, 2016, 28, 3987–4011.
4. Dalong Ni, Zhiwei Shen, Jiawen Zhang, Chen Zhang, Renhua Wu, Jianan Liu, Meizhi Yi, Jing Wang, Zhenwei Yao, Wenbo Bu*, Jianlin Shi
Integrating Anatomic and Functional Dual-Mode Magnetic Resonance Imaging: Design and Applicability of a Bifunctional Contrast Agent.
ACS Nano, 2016, 10 (3), 3783–3790.
5. Jing Wang, Hua Zhang, Dalong Ni, Wenpei Fan, Jianxun Qu, Yanyan Liu, Yingying Jin, Zhaowen Cui, Tianyong Xu, Yue Wu, Wenbo Bu*, Zhenwei Yao*.
High-Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke.
Small, 2016, 12 (26): 3591-3600.
6. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Chen Zhang, Zhenwei Yao, Huaiyong Xing, Jing Wang, Fei Duan, Yanyan Liu, Wenpei Fan, Xiaoyuan Feng, Jianlin Shi*.
PEGylated NaHoF4 nanoparticles as contrast agents for both X-ray computed tomography and ultra-high field magnetic resonance imaging.
Biomaterials, 2016, 76, 218–225.
7. Zhaowen Cui, Wenbo Bu*, Wenpei Fan, Jiawen Zhang, Dalong Ni, Yanyan Liu, Jianan Liu, Jing Wang, Zhenwei Yao, Jianlin Shi*.
Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease.
Biomaterials, 2016, 104, 158-167.
2015年
1. Jianan Liu, Wenbo Bu*, Jianlin Shi*.
Silica Coated Upconversion Nanoparticles: A Versatile Platform for the Development of Efficient Theranostics.
Accounts of Chemical Research, 2015, 48 (7): 1797–1805. (Invited Review).
2. Wenpei Fan, Wenbo Bu*, Zhen Zhang, Bo Shen, Hui Zhang, Qianjun He, Dalong Ni, Zhaowen Cui, Kuaile Zhao, Jiwen Bu, Jiulin Du, Jianan Liu, Jianlin Shi*.
X-ray Radiation-Controlled NO-Release for On-Demand Depth-Independent Hypoxic Radiosensitization.
Angewandte Chemie-International Edition, 2015, 54, 14026–14030.
3. Yanyan Liu, Yong Liu, Wenbo Bu*, Chao Cheng, Changjing Zuo, Qingfeng Xiao, Yong Sun, Dalong Ni, Chen Zhang, Jianan Liu, Jianlin Shi*.
Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.
Angewandte Chemie-International Edition, 2015, 54, 8105–8109.
4. Chen Zhang, Kuaile Zhao, Wenbo Bu*, Dalong Ni, Yanyan Liu, Jingwei Feng, Jianlin Shi*.
Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence.
Angewandte Chemie-International Edition, 2015, 54: 1770–1774.
5. Wenpei Fan, Wenbo Bu*, Bo Shen, Qianjun He, Zhaowen Cui, Yanyan Liu, Xiangpeng Zheng, Kuaile Zhao, Jianlin Shi*.
Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy.
Advanced Materials, 2015, 27, 4155–4161.
6. Wenpei Fan, Bo Shen, Wenbo Bu*, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Kuaile Zhao, Shengjian Zhang, Jianlin Shi*.
Design of An Intelligent Sub-50 nm Nuclear-targeting Nanotheranostic System for Imaging Guided Intranuclear Radiosensitization.
Chemical Science, 2015, 6, 1747–1753.
7. Yanyan Liu, Yong Liu, Wenbo Bu*, Qingfeng Xiao, Yong Sun, Kuaile Zhao, Wenpei Fan, Jianan Liu, Jianlin Shi*.
Radiation-/Hypoxia-induced Solid Tumor Metastasis and Regrowth Inhibited by Hypoxia-specific Upconversion Nanoradiosensitizer.
Biomaterials, 2015, 49: 1–8.
8. Wenpei Fan, Bo Shen, Wenbo Bu*, Xiangpeng Zheng, Qianjun He, Zhaowen Cui, Dalong Ni, Kuaile Zhao, Shengjian Zhang, Jianlin Shi*.
Intranuclear Biophotonics by Smart Design of Nuclear-targeting Photo-/radio-sensitizers Co-loaded Upconversion Nanoparticles.
Biomaterials, 2015, 69: 89–98.
9. Jing Wang, Dalong Ni, Wenbo Bu*, Qian Zhou, Wenpei Fan, Yue Wu, Yanyan Liu, Lekang Yin, Zhaowen Cui, Xiaoxue Zhang, Hua Zhang, Zhenwei Yao*.
BaHoF5 nanoprobes as high-performance contrast agents for multi-modal CT imaging of ischemic stroke.
Biomaterials, 2015, 71: 110–118.
2014年
1. Jianan Liu, Yong Liu, Wenbo Bu*, Jiwen Bu, Yong Sun, Jiulin Du, Jianlin Shi*.
Ultrasensitive Nanosensors Based on Upconversion Nanoparticles for Selective Hypoxia Imaging in Vivo upon Near-Infrared Excitation.
Journal of the American Chemical Society, 2014, 136 (27), 9701–9709.
2. Jianan Liu, Jiwen Bu, Wenbo Bu*, Shengjian Zhang, Limin Pan, Wenpei Fan, Feng Chen, Liangpin Zhou, Weijun Peng, Kuaile Zhao, Jiulin Du, Jianlin Shi*.
Real-Time In Vivo Quantitative Monitoring of Drug Release by Dual-Mode Magnetic Resonance and Upconverted Luminescence Imaging．
Angewandte Chemie-International Edition, 2014, 53, 4551-4555.
3. Huaiyong Xing, Shengjian Zhang, Wenbo Bu*, Xiangpeng Zheng, Lijun Wang, Qingfeng Xiao, Dalong Ni, Jiamin Zhang, Liangping Zhou, Weijun Peng, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
Ultrasmall NaGdF4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging．
Advanced Materials, 2014, 26, 3867–3872.
4. Dalong Ni, Wenbo Bu,* Shengjian Zhang, Xiangpeng Zheng, Ming Li, Huaiyong Xing, Qingfeng Xiao, Yanyan Liu, Yanqing Hua, Liangping Zhou, Wenjun Peng, Kuaile Zhao, Jianlin Shi*.
Single Ho3+-Doped Upconversion Nanoparticles for High-Performance T2-Weighted Brain Tumor Diagnosis and MR/UCL/CT Multimodal Imaging.
Advanced Functional Materials 2014, 24, 6613-6620.
5. Dalong Ni, Jiawen Zhang, Wenbo Bu*, Huaiyong Xing, Fang Han, Qingfeng Xiao, Zhengwei Yao, Feng Chen, Qianjun He, Jianan Liu, Shengjian Zhang, Wenpei Fan, Liangping Zhou, Weijun Peng, Jianlin Shi*.
Dual-Targeting Upconversion Nanoprobes across the Blood-Brain Barrier for Magnetic Resonance/Fluorescence Imaging of Intracranial Glioblastoma.
ACS Nano, 2014, 8 (2), 1231–1242.
6. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Qianjun He, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Dalong Ni, Jianan Liu, Jianlin Shi*.
A Smart Upconversion-based Mesoporous Silica Nanotheranostic System for Synergetic Chemo-/Radio-/Photodynamic Therapy and Simultaneous MR/UCL Imaging.
Biomaterials, 2014, 35: 8992-9002.
2013年
1. Qingfeng Xiao, Xiangpeng Zheng, Wenbo Bu*, Weiqiang Ge, Shengjian Zhang, Feng Chen, Huaiyong Xing, Qingguo Ren, Wenpei Fan, Kuaile Zhao, Yanqing Hua, Jianlin Shi*.
A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy.
Journal of the American Chemical Society, 2013, 135 (35), 13041-13048.
2. Wenpei Fan, Bo Shen, Wenbo Bu*, Feng Chen, Kuaile Zhao, Shengjian Zhang, Liangping Zhou, Weijun Peng, Qingfeng Xiao, Huaiyong Xing, Jianan Liu, Dalong Ni, Qianjun He, Jianlin Shi*.
Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging.
Journal of the American Chemical Society, 2013, 135 (17), 6494-6503.
3. Jianan Liu, Wenbo Bu*, Limin Pan, Jianlin Shi*.
NIR-Triggered Anticancer Drug Delivery by Upconverting Nanoparticles with Integrated Azobenzene-Modified Mesoporous Silica.
Angewandte Chemie-International Edition, 2013, 52, 4375-4379.
4. Feng Chen, Wenbo Bu*, Shengjian Zhang, Jianan Liu, Wenpei Fan, Liangping Zhou, WeijunPeng, Jianlin Shi*.
Gd3+-Ion-Doped Upconversion Nanoprobes: Relaxivity Mechanism Probing and Sensitivity Optimization
Advanced Functional Materials, 2013, 23, 298-307.
2012年
1. Feng Chen, Wenbo Bu*, Shengjian Zhang, Huaiyong Xing, Jianan Liu, Qingfeng Xiao, Xiaohang Liu, Liangping Zhou, Weijun Peng, Lianzhou Wang, Jianlin Shi*.
Positive and Negative Lattice Shielding Effects Co-existing in Gd (III) Ion Doped Bifunctional Upconversion Nanoprobes.
Advanced Functional Materials, 2011, 21, 4285-4294.
2. Qingfeng Xiao, Wenbo Bu*, Qingguo Ren, Shengjian Zhang, Huaiyong Xing, Feng Chen, Ming Li, Xiangpeng Zheng, Yanqing Hua, Liangping Zhou, Weijun Peng, Haiyun Qu, Zheng Wang, Kuaile Zhao, Jianlin Shi*.
Radiopaque fluorescence-transparent TaOx decorated upconversion nanophosphors for in vivo CT/MR/UCL trimodal imaging.
Biomaterials, 2012, 33: 7530-7539.
3. Jianan Liu, Wenbo Bu*, Limin Pan, Shengjian Zhang, Feng Chen, Liangping Zhou, Kuaile Zhao, Weijun Peng, Jianlin Shi*.
Simultaneous Nuclear Imaging and Intranuclear Drug Delivery by Nuclear-Targeted Multifunctional Upconversion Nanoprobes.
Biomaterials, 2012, 33: 7282-7290.
4. Huaiyong Xing, Wenbo Bu*, Qingguo Ren, Xiangpeng Zheng, Ming Li, Shengjian Zhang, Haiyun Qu, Zheng Wang, Yanqing Hua, Kuaile Zhao, Liangping Zhou, Jianlin Shi*.
A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal-imaging.
Biomaterials, 2012, 33, 5384-5393.
5 Huaiyong Xing, Wenbo Bu*, Shengjian Zhang, Xiangpeng Zheng, Ming Li, Feng Chen, Qianjun He, Liangping Zhou, Weijun Peng, Yanqing Hua, Jianlin Shi*.
Multifunctional Nanoprobes for Upconversion Fluorescence, MR and CT Trimodal Imaging.
Biomaterials, 2012, 33, 1079-1089.
