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  • 复旦大学

肖晓 青年研究员 博士生导师

复旦大学类脑智能科学与技术研究院研究员,博士生导师。复旦大学认知神经科学中心执行主任。东方英才计划青年项目(原上海青年拔尖人才),上海市青年科技启明星,“明珠计划”菁英人才,上海市民建科教委员会副主任,上海民建人工智能专委会副主任,中国生理学会青年委员会委员,上海市神经科学学会疼痛转化研究分会委员,民建复旦大学委员会委员。学术专长为使用神经生物学、认知心理学和计算科学等交叉学科的前沿技术,围绕“情感的中枢机制及可塑性调控”这一科学主题,系统研究了情绪记忆的神经生理机制,推动了情感障碍中枢机制研究的发展及临床诊疗应用,并建立了一系列行为心理治疗为基础的创新技术。在神经生物学权威期刊:Cell Repo...

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在研项目:

  • 基于神经环路可塑性机制的情绪情感调控,科技部科技创新2030-重大项目,2021-2025,200万

  • 小鼠MID 行为学范式的建立及神经作用机制研究,原创性科研项目,2020-2021,10万

  • 类脑智能算法的验证与实践,科技部国家重点研发计划,2020-2025,170万

  • 疼痛-抑郁共病神经环路的优先级效应,国家自然科学基金,2020-2023,25万

  • 虚拟现实对改善慢性痛诱导抑郁症的神经环路机制,上海市科委启明星项目,2019-2022,40万

  • 疼痛-抑郁共病的神经环路和分子机制,上海市科委重大专项子项目,2018-2023,49.84万

  • 虚拟现实对改善情绪和记忆功能的神经环路机制,复旦大学,2018-2022,100万


代表论文:

1.      Integrin α3 Is Required for High-Frequency Repetitive Transcranial Magnetic Stimulation–Induced Glutamatergic Synaptic Transmission in Mice with Ischemia. Li Liu*, Han Hu*, Junfa Wu*, Anthony J. Koleske, Hongting Chen, Nianhong Wang, Kewei Yu, Yi Wu#, Xiao Xiao#, Qun Zhang#, CNS Neuroscience & Therapeutics, (2023) accepted

2.      Deep learning-based activity recognition and fine motor identification with 2D skeleton in cynomolgus monkeys. Chuxi Li*, Zifan Xiao*, Yerong Li, Zhinan Chen, Xun Ji, Yiqun Liu, Shufei Feng, Zhen Zhang, Kaiming Zhang, Jianfeng Feng, Trevor W. Robbins, Shisheng Xiong#, Yongchang Chen, Xiao Xiao#, Zoological Research, (2023) 44(5): 967-980.   doi: 10.24272/j.issn.2095-8137.2022.449

3.      Serpin family proteins as potential biomarkers and therapeutic drugs in stroke: A systematic review and meta-­analysis on clinical/preclinical studies. Bing Yan, Lu Luo, Li Liu, Zhenyu Wang, Ruiying Chen, Yi Wu, Xiao Xiao#, CNS Neuroscience & Therapeutics, (2023) 00:1–12.

4.      Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats. Li Liu, Ming Ding, Junfa Wu, Yuwen Zhang, Shaoqian Guo, Nianhong Wang, Kewei Yu, Lu Luo, Qianfeng Wang, Yuanfeng Weng, Quan Zhang, Kai Qiu, Yi Wu#, Xiao Xiao#, Qun Zhang#, Frontiers in Neuroscience, (2023) DOI: 10.3389/fnins.2023.1129590

5.      广义线性模型在神经电生理信号分析中的应用。 刘子悦; 肖晓#复旦学报(自然科学版), (2023), DOI:10.15943/j.cnki.fdxb-jns.20230318.001

6.      A tassel-type multilayer flexible neural probe prepared by laser direct writing. Zipeng Ye, Jing Qi, Yiling Ni, Zhiyong Wu, Xiao Xiao#, Shisheng Xiong#, Chip, (2022). 1 (3), 100024. DOI: 10.1016/j.chip.2022.100024 (Cover paper)

7.      Corticospinal circuit neuroplasticity may involve silent synapses: implications for functional recovery facilitated by neuromodulation after spinal cord injury. Mingcong Chen, Zuxin Chen, Xiao Xiao, Libing Zhou, Rao Fu, Xian Jiang, Mao Pang, Jianxun Xia#, IBRO Neuroscience Reports (2022). 14, 185-194

8.      The role of glia underlying acupuncture analgesia in animal pain models, a systematic review and meta-analysis. Bing Yan, Shengyu Tang, Yuqiu Zhang, Xiao Xiao#, Pain Medicine (2022). , 24 (1), 11-24;  doi: 10.1093/pm/pnac115

9.      影响老年人认知健康的街区环境要素——基于2000—2021年国际研究进展。袁琦; 陈泳#;肖晓, 新建筑, 2022, (03): 146-150.

10.   Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice. Lu Luo*, Meixi Liu*, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao#, Yi Wu#, Journal of Neuroinflammation (2022) 19:141

11.   Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients. Huichun Luo*, Yongzhi Huang*, Alexander L. Green, Tipu Z. Aziz, Xiao Xiao, Shouyan Wang#, NeuroImage: Clinical (2021). 32, 102876

12.   MonkeyPosekit: Automated Markerless 2D Pose Estimation of Monkey, Chuxi Li, Chi Yang, Yerong Li, Shufei Feng, Zhen Zhang, Shisheng Xiong#, Xiao Xiao#, IEEE- China Automation Congress (CAC) (2021) 1280-1284

13.   基于时移和片组注意力融合的双流行为识别网络. 肖子凡, 刘逸群, 李楚溪, 张力, 王守岩, 肖晓#计算机系统应用 Computer Systems & Applications, (2022) 31(1):204211

14.   The role of the anterior cingulate cortex in translational pain research. Xiao Xiao#, Ming Ding, Yuqiu Zhang#, Neuroscience Bulletin (2021) 37(3), 405-422

15.   Distinct function of estrogen receptors in the rodent anterior cingulate cortex in pain-related aversion. Kai-Kai Zang *, Xiao Xiao*,Li-Qiang Chen,Yan Yang, Qi-Lai Cao, Yu-Long Tang, Su-Su Lv, Hong Cao, Ling Zhang, Yu-Qiu Zhang. Anesthesiology (2020) Jul;133(1):165-184;

16.   Functional dynamics of thalamic local field potentials correlated with modulation of neuropathic pain. Huichun Luo, Yongzhi Huang, Xiao Xiao, Wenjing Dai, Yingnan Nie, Xinyi Geng, Yongzhi Huang, Alex Green, Tipu Aziz, Shouyan Wang#, European Journal of Neuroscience. (2020) 51:628–640

17.   Trio haploinsufficiency causes neurodevelopmental disease-associated deficits. Sara M. Katrancha, Amy Zhao, Amanda Jeng, Juliana Shaw, Minsheng Zhu, Christopher Pittenger, Charles Greer, Xiao Xiao#, Anthony J. Koleske# Cell Reports. (2019) 26:2805-2817

18.   A new perspective on the anterior cingulate cortex and affective pain. Xiao Xiao, Yuqiu Zhang*. Neuroscience & Biobehavioral Reviews (2018) 90:200-211

19.   Noonan syndrome-associated SHP2 dephosphorylates GluN2B to regulate NMDA receptor function. Aaron D. Levy*, Xiao Xiao*, Suma Priya Sudarsana Devi, Anton M. Bennett, Charles A. Greer, James R. Howe, Kazuya Machida, Anthony J. Koleske# Cell Reports (2018) 24 (6):1523-1535

20.   CNS neurons deposit Laminin α5 to stabilize synapses. Mitchell H. Omar, Maghan Kerrisk Campbell, Xiao Xiao, Qiaonan Zhong, William J. Brunken, Jeffrey H. Miner, Charles A. Greer, Anthony J. Koleske#, Cell Reports (2017) 21(5): 1281-1292

21.   Disruption of coordinated presynaptic and postsynaptic maturation underlies the defects in hippocampal synapse stability and plasticity in Abl2/Arg-deficient mice. Xiao Xiao, Aaron D. Levy, Brian J. Rosenberg, Michael J. Higley, Anthony J. Koleske#, Journal of Neuroscience, (2016) 36 (25): 6778-6791

22.   SIP 30 Is Required for Neuropathic Pain-Evoked Aversion in Rats. Mei Han, Xiao Xiao, Yan Yang, Ru-Yi Huang, Hong Cao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Neuroscience,(2014) 34(2): 346-355

23.   Estrogen in the anterior cingulate cortex contributes to pain-related aversion. Xiao Xiao, Yan Zhang, Yan Yang, Zhi-Qi Zhao, Yu-Qiu Zhang#, Cerebral Cortex (2012) 23(9): 2190-2203

24.   Estrogen facilitates spinal cord synaptic transmission via mambrane-bound estrogen receptors: implications for pain hypersensitivity. Yan Zhang, Xiao Xiao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Biological Chemistry,(2012) 287(40):33268-81

25.   综述:一念放下,万般自在——我们能否训练自己去遗忘疼痛. 肖晓, 生理学报Acta Physiologica Sinica, June 25, 2011, 63(3): 293–295

26.   NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Ting-Ting Li*, Wen-Hua Ren*, Xiao Xiao*, Long-Zhen Cheng, Xue-Han Zhang, Zhi-Qi Zhao, Yu-Qiu Zhang#. Pain, (2009) 146, 183–193