在研项目：

• 整合素α3蛋白缺失引发小鼠ADHD样行为的神经机制研究，国家自然科学基金（面上项目），2025-2028，51万

• 虚拟现实疗法改善疼痛抑郁共病的神经机制和临床应用，上海市东方英才拔尖专项，2025-2028，40万

• 基于神经环路可塑性机制的情绪情感调控，科技部科技创新2030-重大项目，2021-2025，200万

• 小鼠MID 行为学范式的建立及神经作用机制研究，原创性科研项目，2020-2021，10万
  

• 类脑智能算法的验证与实践，科技部国家重点研发计划，2020-2025，170万

• 疼痛-抑郁共病神经环路的优先级效应，国家自然科学基金，2020-2023，25万

• 虚拟现实对改善慢性痛诱导抑郁症的神经环路机制，上海市科委启明星项目，2019-2022，40万

• 疼痛-抑郁共病的神经环路和分子机制，上海市科委重大专项子项目，2018-2023，49.84万

• 虚拟现实对改善情绪和记忆功能的神经环路机制，复旦大学，2018-2022，100万

代表论文：

1.      Downregulation of Integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression. Xiaojuan Yao*, Ruiying Chen*, Jingxiang Zhu*, Ruiqing Hou, Shitong Xiang, Tianye Jia, Yuelin Gu, Zhenyv Wang, Han Hu, Hongting Chen, He Wang, Jianfeng Feng, Trevor Robbins, Yingwei Wang#, Michael Higley, Antony Koleske, Xiao Xiao#, Molecular Psychiatry (2025), In Press

2.      Cracking the Valence Code: Patterned Facial Kinematics and Neural Signatures of Emotional Expressions in Mice. Yujia Chen, Ruiqing Hou, Zhinan Chen, Junli Lu, Si Chen, Shisheng Xiong, Jianfeng Feng, Trevor W. Robbins, Haitao Yan, Xiao Xiao#, Advanced Science (2025), 12 (42), e17156

3.      Ultrabright Ratiometric Raman-guided Epilepsy Surgery by Intraoperatively Visualizing Proinflammatory Microglia. Cong Wang, Zhi Li, Xiao Zhu, Yiqing Jiang, Wenjia Duan, Wanbing Sun, Ming Chen, Jiayi Hu, Zeping Cai, Xingyu Zhou, Xiao Xiao#, Liang Chen#, Cong Li# and Ying Mao#, Cell Reports Medicine (2025), 6 (6), 102155

4.      Disentangling distinct neural circuits for emotional evaluation and uncertainty in the human amygdala underlying different mental disorders. Shitong Xiang, Chao Xie, Xiao Xiao, Wei Cheng, Tobias Banaschewski, Gareth J. Barker, Gunter Schumann, Benjamin Becker, Trevor W. Robbins#, Tianye Jia#, Jianfeng Feng#, IMAGEN Consortium and Stratify Consortium. Science Bulletin, (2025), S2095-9273(25)00188-4. doi: 10.1016/j.scib.2025.02.026.

5.      Large-scale plasma proteomics to profile pathways and prognosis of chronic pain. Zeyu Li*, Qing Ma*, Jie Zhang*, Qizheng Hao*, Jia You, Xinrui Wu, Jujiao Kang, Linbo Wang, Yueting Deng, Yuzhu Li, Chun Shen, Bangsheng Wu, Jianfeng Feng, Yiheng Tu, Xiao Xiao#, Jintai Yu#, Wei Cheng#, Advanced Science, (2025), 12 (16), 2410160

6.      Effects of intermittent theta burst stimulation on the inflammatory response and cerebral blood flow in promoting neurovascular repair after ischemic stroke. Jingjun Zhang, Siyue Li, Dan Huang, Jiale Fu, Shuying Chen, Na Ren, Pengkun Yang, Di Song, Xiaochen Bai, Hongyu Xie, Gang Liu, Kewei Yu, Shamay SM Ng, Junfa Wu, Xiao Xiao#, Yi Wu#, Molecular Brain (2025), 18 (1), 1-13

7.      Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients. Dan Liu, Menghan Li, Heng Jiang, Yiqi Mi, Xiaolei Xu, Yali Zhou, Yaxian Hou, Yuquan Shen, Michael Maes, Xiao Xiao, Feng Zhou, Luca Giani, Keith M Kendrick, Benjamin Becker, Stefania Ferraro. The Journal of Headache and Pain (2025), 26(1),1-18

8.      Intermittent theta-burst stimulation modulates glial cells via PI3K/AKT to improve the neurovascular unit in stroke mice. Jingjun Zhan*, Ming Ding*, Lu Luo, Dan Huang, Siyue Li, Shuying Chen, Yunhui Fan, Li Liu, Hongyu Xie, Gang Liu, Kewei Yu, Junfa Wu, Xiao Xiao#, Yi Wu#, Neural Regeneration Research, (2025), 21(0), 10.4103/NRR.NRR-D-24-01189

9.      Effects of electroacupuncture per-conditioning at Huantiao on motor function recovery in acute cerebral ischemia mice. Jia-le Fu, Jing-Jun Zhang, Yi Wu, Nian-hong Wang, Qi Qi, Guo-hui Yang, Na Ren, Dan Huang, Yun Li, Li-juan Zhao, Xiao Cui#, Xiao Xiao#, Hong-yu Xie#, Physiology & Behavior, (2025), 292, 114814

10.   Intermittent vibration induces sleep via an allatostatin A-GABAsignaling pathway and ameliorates memory impairment in Alzheimer's disease models. Yang Mou, Yan Zhang, Yuxian Zheng, Guang He, Zhi-Xiang Xu, Xiao Xiao#, Yong Ping#, Advanced Science, (2024), 12 (5), https://doi.org/10.1002/advs.202411768

11.   Coordinated interactions between the hippocampus and retrosplenial cortex in spatial memory. Ruiqing Hou, Ziyue Liu, Zichen Jin, Dongxue Huang, Yue Hu, Wenjie Du, Danyi Zhu, Leiting Yang, Yuanfeng Weng, Tifei Yuan, Yingwei Wang, Bin Lu, Yong Ping#, Xiao Xiao#, Research, (2024), Volume 7, 0521

12.   Differential efficacy of modified enriched environment on motor, emotion, and cognition in cortical ischemic mice. Dan Huang, Yunhui Fan, Jingjun Zhang, Yuanfeng Weng, Xiao Xiao#, Yi Wu#, Junfa Wu#, Cerebral Cortex, Volume 34, Issue 9, September 2024, bhae375, https://doi.org/10.1093/cercor/bhae375

13.   Impact of abl2/arg deficiency on anxiety and depressive behaviors in mice. Xiaojuan Yao, Ruiying Chen, Hongting Chen, Anthony Koleske, Xiao Xiao#, Behavioural Brain Research, (2024), Volume 468, 115022, https://doi.org/10.1016/j.bbr.2024.115022

14.   Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice. Dan Huang, Yunhui Fan, Jingjun Zhang, Qianfeng Wang, Ming Ding, Ruiqing Hou, Kewei Yu, Xiao Xiao#, Yi Wu#, Junfa Wu#, Experimental Neurology, (2024) Volume 377, 114801, https://doi.org/10.1016/j.expneurol.2024.114801

15.   小鼠二选一赌博实验范式设计及验证。古玥琳，肖晓#，山东大学学报（医学版），（2024）第62卷，第三期

16.   High-frequency repetitive transcranial magnetic stimulation promotes ipsilesional functional hyperemia and motor recovery in mice with ischemic stroke. Li Liu*, Ming Ding*, Junfa Wu, Yuwen Zhang, Qianfeng Wang, Nianhong Wang, Lu Luo, Kewei Yu, Yunhui Fan, Jingjun Zhang, Yi Wu#, Xiao Xiao#, Qun Zhang#, Cerebral Cortex (2024), 34 (3), bhae074

17.   Integrin α3 Is Required for High-Frequency Repetitive Transcranial Magnetic Stimulation–Induced Glutamatergic Synaptic Transmission in Mice with Ischemia. Li Liu*, Han Hu*, Junfa Wu*, Anthony J. Koleske, Hongting Chen, Nianhong Wang, Kewei Yu, Yi Wu#, Xiao Xiao#, Qun Zhang#, CNS Neuroscience & Therapeutics, (2023), 30 (4), e14498.

18.   Deep learning-based activity recognition and fine motor identification with 2D skeleton in cynomolgus monkeys. Chuxi Li*, Zifan Xiao*, Yerong Li, Zhinan Chen, Xun Ji, Yiqun Liu, Shufei Feng, Zhen Zhang, Kaiming Zhang, Jianfeng Feng, Trevor W. Robbins, Shisheng Xiong#, Yongchang Chen, Xiao Xiao#, Zoological Research, (2023) 44(5): 967-980.  doi:10.24272/j.issn.2095-8137.2022.449

19.   Serpin family proteins as potential biomarkers and therapeutic drugs in stroke: A systematic review and meta-­analysis on clinical/preclinical studies. Bing Yan, Lu Luo, Li Liu, Zhenyu Wang, Ruiying Chen, Yi Wu, Xiao Xiao#, CNS Neuroscience & Therapeutics, (2023) 29(7): 1738–1749.

20.   Design and evaluation of a rodent-specific focal transcranial magnetic stimulation coil with the custom shielding application in rats. Li Liu, Ming Ding, Junfa Wu, Yuwen Zhang, Shaoqian Guo, Nianhong Wang, Kewei Yu, Lu Luo, Qianfeng Wang, Yuanfeng Weng, Quan Zhang, Kai Qiu, Yi Wu#, Xiao Xiao#, Qun Zhang#, Frontiers in Neuroscience, (2023) DOI: 10.3389/fnins.2023.1129590

21.   广义线性模型在神经电生理信号分析中的应用。 刘子悦; 肖晓#，复旦学报（自然科学版）, (2023), DOI:10.15943/j.cnki.fdxb-jns.20230318.001

22.   A tassel-type multilayer flexible neural probe prepared by laser direct writing. Zipeng Ye, Jing Qi, Yiling Ni, Zhiyong Wu, Xiao Xiao#, Shisheng Xiong#, Chip, (2022). 1 (3), 100024. DOI: 10.1016/j.chip.2022.100024 (Cover paper)

23.   Corticospinal circuit neuroplasticity may involve silent synapses: implications for functional recovery facilitated by neuromodulation after spinal cord injury. Mingcong Chen, Zuxin Chen, Xiao Xiao, Libing Zhou, Rao Fu, Xian Jiang, Mao Pang, Jianxun Xia#, IBRO Neuroscience Reports (2022). 14, 185-194

24.   The role of glia underlying acupuncture analgesia in animal pain models, a systematic review and meta-analysis. Bing Yan, Shengyu Tang, Yuqiu Zhang, Xiao Xiao#, Pain Medicine (2022). , 24 (1), 11-24;  doi: 10.1093/pm/pnac115

25.   影响老年人认知健康的街区环境要素——基于2000—2021年国际研究进展。袁琦; 陈泳#;肖晓, 新建筑, 2022, (03): 146-150.

26.   Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice. Lu Luo*, Meixi Liu*, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Hongyu Xie, Congyu Jiang, Junfa Wu, Xiao Xiao#, Yi Wu#, Journal of Neuroinflammation (2022) 19:141

27.   Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients. Huichun Luo*, Yongzhi Huang*, Alexander L. Green, Tipu Z. Aziz, Xiao Xiao, Shouyan Wang#, NeuroImage: Clinical (2021). 32, 102876

28.   MonkeyPosekit: Automated Markerless 2D Pose Estimation of Monkey, Chuxi Li, Chi Yang, Yerong Li, Shufei Feng, Zhen Zhang, Shisheng Xiong#, Xiao Xiao#, IEEE- China Automation Congress (CAC) (2021) 1280-1284

29.   基于时移和片组注意力融合的双流行为识别网络。肖子凡, 刘逸群, 李楚溪, 张力, 王守岩, 肖晓#，计算机系统应用 Computer Systems & Applications, (2022) 31(1):204−211

30.   The role of the anterior cingulate cortex in translational pain research. Xiao Xiao#, Ming Ding, Yuqiu Zhang#, Neuroscience Bulletin (2021) 37(3), 405-422

31.   Distinct function of estrogen receptors in the rodent anterior cingulate cortex in pain-related aversion. Kai-Kai Zang *, Xiao Xiao*,Li-Qiang Chen,Yan Yang, Qi-Lai Cao, Yu-Long Tang, Su-Su Lv, Hong Cao, Ling Zhang, Yu-Qiu Zhang. Anesthesiology (2020) Jul;133(1):165-184;

32.   Functional dynamics of thalamic local field potentials correlated with modulation of neuropathic pain. Huichun Luo, Yongzhi Huang, Xiao Xiao, Wenjing Dai, Yingnan Nie, Xinyi Geng, Yongzhi Huang, Alex Green, Tipu Aziz, Shouyan Wang#, European Journal of Neuroscience. (2020) 51:628–640

33.   Trio haploinsufficiency causes neurodevelopmental disease-associated deficits. Sara M. Katrancha, Amy Zhao, Amanda Jeng, Juliana Shaw, Minsheng Zhu, Christopher Pittenger, Charles Greer, Xiao Xiao#, Anthony J. Koleske# Cell Reports. (2019) 26:2805-2817

34.   A new perspective on the anterior cingulate cortex and affective pain. Xiao Xiao, Yuqiu Zhang#. Neuroscience & Biobehavioral Reviews (2018) 90:200-211

35.   Noonan syndrome-associated SHP2 dephosphorylates GluN2B to regulate NMDA receptor function. Aaron D. Levy*, Xiao Xiao*, Suma Priya Sudarsana Devi, Anton M. Bennett, Charles A. Greer, James R. Howe, Kazuya Machida, Anthony J. Koleske# Cell Reports (2018) 24 (6):1523-1535

36.   CNS neurons deposit Laminin α5 to stabilize synapses. Mitchell H. Omar, Maghan Kerrisk Campbell, Xiao Xiao, Qiaonan Zhong, William J. Brunken, Jeffrey H. Miner, Charles A. Greer, Anthony J. Koleske#, Cell Reports (2017) 21(5): 1281-1292

37.   Disruption of coordinated presynaptic and postsynaptic maturation underlies the defects in hippocampal synapse stability and plasticity in Abl2/Arg-deficient mice. Xiao Xiao, Aaron D. Levy, Brian J. Rosenberg, Michael J. Higley, Anthony J. Koleske#, Journal of Neuroscience, (2016) 36 (25): 6778-6791

38.   SIP 30 Is Required for Neuropathic Pain-Evoked Aversion in Rats. Mei Han, Xiao Xiao, Yan Yang, Ru-Yi Huang, Hong Cao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Neuroscience,(2014) 34(2): 346-355

39.   Estrogen in the anterior cingulate cortex contributes to pain-related aversion. Xiao Xiao, Yan Zhang, Yan Yang, Zhi-Qi Zhao, Yu-Qiu Zhang#, Cerebral Cortex (2012) 23(9): 2190-2203

40.   Estrogen facilitates spinal cord synaptic transmission via mambrane-bound estrogen receptors: implications for pain hypersensitivity. Yan Zhang, Xiao Xiao, Zhi-Qi Zhao, Yu-Qiu Zhang#, Journal of Biological Chemistry,(2012) 287(40):33268-81

41.   综述：一念放下，万般自在——我们能否训练自己去遗忘疼痛. 肖晓, 生理学报Acta Physiologica Sinica, June 25, 2011, 63(3): 293–295

42.   NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats. Ting-Ting Li*, Wen-Hua Ren*, Xiao Xiao*, Long-Zhen Cheng, Xue-Han Zhang, Zhi-Qi Zhao, Yu-Qiu Zhang#. Pain, (2009) 146, 183–193